Guile or Guilé may refer to:
Fictional characters Guile (Street Fighter), a video game character from the Street Fighter series Guile, a video game character from Chrono Cross
People Daniel Guile (1814–1882), British trade unionist Melanie Guile (born 1949), Australian writer
Other uses Deception, and astuteness GNU Guile, an implementation of the Scheme programming language Guile Island, Antarctica Guilé Foundation, a Swiss organisation for business ethics
See also Guille (disambiguation)