James H. Duff (1883–1969) was a U.S. Senator from Pennsylvania from 1951 to 1957. Senator Duff may also refer to:
Bob Duff (born 1971), Connecticut State Senate Hugh Duff (politician) (1870/71–1940), Senate of Northern Ireland Philip S. Duff (1922–1997), Minnesota State Senate Scott Duff (1950–2020), Oregon State Senate
See also Senator Duffy (disambiguation) Senator Duffield (disambiguation)