The Women's 4 × 50 metre freestyle relay competition of the 2022 FINA World Swimming Championships (25 m) was held on 15 December 2022.

Records Prior to the competition, the existing world and championship records were as follows.

The following new records were set during this competition: Date Event Name Nation Time Record 15 December Final Torri Huske (24.08)Claire Curzan (23.30)Erika Brown (23.74)Kate Douglass (22.77) 1:33.89 CR

Results Heats The heats were started at 12:52.

Rank Heat Lane Nation Swimmers Time Notes 1 1 5 Zhang Yufei (23.76) NRLiu Shuhan (24.06)Cheng Yujie (24.10)Yang Junxuan (24.16) 1:36.08 Q 2 1 2 Meg Harris (23.85)Alexandria Perkins (24.10)Brittany Castelluzzo (24.29)Mollie O'Callaghan (23.90) 1:36.14 Q, OC 3 1 3 Erika Brown (24.16)Erin Gemmell (24.34)Natalie Hinds (23.92)Alexandra Walsh (23.75) 1:36.17 Q 4 1 4 Kim Busch (24.06)Maaike de Waard (23.65)Valerie van Roon (23.75)Tessa Vermeulen (24.86) 1:36.32 Q 5 1 6 Anna Hopkin (23.99)Isabella Hindley (24.19)Imogen Clark (24.60)Abbie Wood (24.63) 1:37.41 Q 6 1 7 Yume Jinno (24.76)Miki Takahashi (24.33)Chihiro Igarashi (24.35)Ai Soma (24.30) 1:37.74 Q 7 2 2 Sara Junevik (24.30)Sofia Åstedt (24.53)Sophie Hansson (24.52)Hanna Rosvall (24.58) 1:37.93 Q 8 2 3 Helena Gasson (24.99)Rebecca Moynihan (24.10)Emma Godwin (24.38)Erika Fairweather (24.98) 1:38.45 Q, NR 9 2 3 Sze Hang-yu (24.93)Stephanie Au (24.68)Ho Nam Wai (25.65)Chan Kin Lok (25.10) 1:40.36 10 2 5 Teresa Ivanová (24.61) NR Martina Cibulková (25.87)Zora Ripková (25.51)Lillian Slušná (24.79) 1:40.78 NR 11 2 6 Caitlin de Lange (24.33) NRRebecca Meder (25.14)Emily Visagie (26.08)Milla Drakopoulos (25.25) 1:40.80 AF 12 2 7 Rafaela Fernandini (25.18) NRMcKenna DeBever (25.20)Maria Fe Muñoz (27.22)Alexia Sotomayor (26.24) 1:43.84 NR

Final The final was held at 21:46.

Rank Lane Nation Swimmers Time Notes 3 Torri Huske (24.08)Claire Curzan (23.30)Erika Brown (23.74)Kate Douglass (22.77) 1:33.89 CR, AM 5 Meg Harris (23.98)Madison Wilson (23.51)Mollie O'Callaghan (24.01)Emma McKeon (22.73) 1:34.23 OC 6 Kim Busch (24.20)Maaike de Waard (23.47)Kira Toussaint (24.01)Valerie van Roon (23.68) 1:35.36 4 1 Sara Junevik (24.13)Michelle Coleman (23.28)Louise Hansson (23.78)Sophie Hansson (24.49) 1:35.68 5 4 Yang Junxuan (24.24)Cheng Yujie (23.67)Liu Shuhan (24.06)Wang Yichun (24.15) 1:36.12 6 2 Anna Hopkin (23.94)Isabella Hindley (24.37)Imogen Clark (24.18)Abbie Wood (24.62) 1:37.11 7 7 Chihiro Igarashi (24.54)Miki Takahashi (24.43)Yume Jinno (24.47)Ai Soma (23.98) 1:37.42 8 8 Helena Gasson (24.82)Rebecca Moynihan (24.13)Emma Godwin (24.40)Erika Fairweather (24.58) 1:37.93 NR

References