Lespinasse or de Lespinasse may refer to:
Lespinasse (restaurant), a former restaurant in Manhattan, New York Lespinasse, Haute-Garonne, France
People Augustin de Lespinasse (1737–1816), French military leader Ernest Lespinasse (1897–1927), French Olympic gymnast Gabrielle Lespinasse (1888–c. 1970), French muse for the Spanish artist Pablo Picasso Jeanne Julie Éléonore de Lespinasse (1732–1776), French salon holder René de Lespinasse (1843–1922), French historian and politician
See also Lespinassière, Aude, France Saint-Forgeux-Lespinasse, Loire, France Saint-Germain-Lespinasse, Loire, France Saint-Jean-Lespinasse, Lot, France Saint-Vincent-Lespinasse, Tarn-et-Garonne, France Espinasse (disambiguation)