La Reine can refer to

Organizations Régiment de La Reine, a regiment of the French Army of the Ancien Régime

Places La Reine, Quebec, a municipality in Quebec, Canada La Reine, a populated place in the commune of Saint-Priest-des-Champs, Puy-de-Dôme, France La Reine, U.S. Virgin Islands

See also Reine, Norway "Reine" (song)