USS Natchez may refer to the following ships operated by the United States Navy:
, a sloop-of-war launched in 1827. , the name and designation of USS Oceanographer (AGS-3) from April to May 1942 , an patrol frigate, launched in 1942, served in World War II; sold to Dominican Republic in 1948 and served as Juan Pablo Duarte (F–102) until she sank in 1957.
See also , civilian vessels named Natchez