Oswegatchie may refer to:
In New York Oswegatchie, New York, a town in St. Lawrence County Oswegatchie River, a tributary of the Saint Lawrence River Oswegatchie people, a native people of northern New York Fort Oswegatchie, subsequent name of Fort de La Présentation Oswegatchie Corners, a location in the town of Diana, New York
Elsewhere Oswegatchie Historic District, a location in the town of Waterford, Connecticut