Heyne is a German surname. Notable people with the surname include:
Alexander Heyne (1869-1927), German bookseller, specimen trader and entomologist Benjamin Heyne (1770–1819), botanist, naturalist, and surgeon Christian Gottlob Heyne (1729–1812), German classical scholar and archaeologist Dirk Heyne (born 1957), German football player and manager Ernst Bernard Heyne (1825–1881), German botanist Karel Heyne (1877–1947), Dutch botanist Moritz Heyne (1837–1906), Germanic linguist Paul Heyne (1931–2000), American economist
See also Heyne (singer), South Korean singer Heyne Verlag, a German imprint of publishers Random House Heine, also a surname Chayyim, the basis for this name and similar spellings