De novo (Latin, , used in English to mean 'from the beginning', 'anew') may refer to:
Science and computers De novo mutation, a new germline mutation not inherited from either parent De novo protein design, the creation of a protein sequence that is not based on existing, natural sequences De novo protein structure prediction, the prediction of a protein's 3D structure, based only on its sequence De novo synthesis of complex molecules from simple molecules in chemistry De novo transcriptome assembly, the method of creating a transcriptome without a reference genome, using de novo sequence assembly De novo gene birth, the emergence of genes from non-coding sequence De novo domestication, the domestication of new species for human use De novo assembly in genomics De Novo classification, a pathway to classify new medical devices provided by the US Federal Food, Drug, and Cosmetic Act Denovo, a supercomputer project that simulates nuclear reactions; see
Other De novo review, an appellate standard of review for legal issues Trial de novo, or a new trial in the legal system De novo bank, a state bank that has been in operation for five years or less De Novo, a public housing estate in Kai Tak, Hong Kong Denovo (band), a 1980s Italian new wave group