LRU may refer to:

Organisations Latvian Russian Union, a political party in Latvia Lenoir–Rhyne University, US Lithuanian Riflemen's Union, a paramilitary organisation in Lithuania London Reform Union, a former campaigning group of the Progressive Party

Other uses Lance-roquettes unitaire, a variant of the M270 Multiple Launch Rocket System in service with the French Army Las Cruces International Airport (IATA code), US Least recently used, a cache replacement algorithm The least recently used page replacement algorithm in virtual memory management Liberties and Responsibilities of Universities, a French law voted in 2007 Line-replaceable unit, a modular component of an airplane or other manufactured device