Casillas de Flores is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon. It is located from the city of Salamanca and as of 2016 has a population of 183 people. The municipality covers an area of .

The village lies above sea level and the post code is 37541.

History The village was founded by Alfonso VI in about 1650. It is known for its position on a smuggling route connecting Spain to Portugal. During the 1960s many of the residents emigrated to (then) more economically dynamic places such as France, Switzerland and the Basque country.

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