Galactosylceramidase (or galactocerebrosidase), , is an enzyme that removes galactose from ceramide derivatives (galactosylceramides) by catalysing the hydrolysis of galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.
It is a lysosomal protein, encoded in humans by the GALC gene. Mutations in this gene have been associated with Krabbe disease, also known as galactosylceramide lipidosis.
References
Further reading
External links GeneReviews/NCBI/NIH/UW entry on Krabbe disease OMIM entries on Krabbe disease
PDBe-KB provides an overview of all the structure information available in the PDB for Mlouse Galactocerebrosidase